Anybody have trouble with their mouse locking up?

Over several weeks, I have had my mouse lock up. I run Win XP Pro with a Logitech MX500 mouse. I have tried to roll back the driver, update the driver, uninstall and reinstall the driver. It appears the only thing that seems to be running all the time when the mouse locks is BOINC but I could be wrong. Just wondered if anyone else is having the problem. I have to unplug the USB and replug it until it recognizes it before the mouse unfreezes. This can happen 20 or more times a day.